Legend of Zelda
Modern
F4hybrid
First 48
Top flavors
earthyspicycitrus
Terpenes
CalmingEnergizing
First 48 effects are mostly calming.
First 48
First 48 is a modern hybrid strain derived from the Orange Blossom Trail lineage. This variety is designed for growers who require a moderately difficult challenge, with plants that finish their flowering cycle in exactly 56 days. The strain is well-suited for both indoor and outdoor cultivation environments and is capable of producing a high yield upon harvest.
The chemical profile of First 48 is led by a dominant presence of myrcene, followed by secondary caryophyllene and tertiary limonene. This specific terpene composition dictates the sensory experience, offering a distinct aromatic and flavor nuance shaped by these three compounds.
Users of First 48 typically report feelings of being relaxed, happy, and uplifted. These effects make the strain a functional choice for those seeking to manage stress, alleviate pain, or improve sleep quality. The genetic legacy of this hybrid is further evidenced by its status as the parent of the notable offspring known as Kreemsycle.
Terpene Profile
Synergies (+) and conflicts (−) are relative to each other within this profile.
myrcene ~60%caryophyllene ~28%limonene ~12%
| Terpene | Share | Character | Likely role |
|---|---|---|---|
| myrcene | ~60% | earthy | relaxing · solo |
| caryophyllene | ~28% | spicy | relaxing · social |
| limonene | ~12% | citrus | social · creative |
Research notes below describe isolated terpene mechanisms and early findings. They do not guarantee effects from this strain and are not medical advice.
Russo 2011: naloxone-sensitive analgesia, potentiates barbiturate sleep; dominant sedating terpenoid; blocks hepatic carcinogenesis by aflatoxin.
~28%
spicy
●●○○
Russo 2011: only terpene that is a selective full CB2 agonist (100 nM); Gertsch et al. 2008: acts as dietary cannabinoid; unique anti-inflammatory and gastric cytoprotective properties.
Russo 2011: increases serotonin in prefrontal cortex + dopamine in hippocampus via 5-HT1A; Johns Hopkins 2024: significantly reduced anxiety vs THC alone.
Effects
Reported effects — derived from terpene chemistry and cannabinoid profile.
◎
relaxed
eveningPrimary endpoint of myrcene+linalool sedating combinations; GABA modulation is the dominant mechanistic driver.
◉
happy
anytime△
uplifted
morningLimonene anxiolytic/antidepressant via serotonin elevation in prefrontal cortex (Russo 2011); mood improvement without full euphoria; key for balanced-1-1 profiles.
Genetic Profile
Balanced Hybrid
■ Indica 50%■ Sativa 50%
Equal indica and sativa genetics. Balanced body and mind effects.
THC-Dominant
High THC, trace CBD. Psychoactive. Full CB1 agonism — euphoria, appetite, analgesia.
Genealogy
Parentage, ancestry, and genetic relatives of First 48.
Composite Traits
Where to buy First 48
No verified dispensaries on file — find it on Leafly.
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What would First 48 × ? produce?
Predict the terpene profile, effects, and growing traits of a cross. Our gene weaver engine votes on dominant traits from both parents.
Build a cross with First 48 →Similar strains
Same primary terpene with overlapping effects.
Frequently Asked Questions
Is First 48 indica or sativa?
First 48 is modeled here as a balanced hybrid (equal indica and sativa genetics).
What terpene is dominant in First 48?
Myrcene is shown as the dominant terpene at approximately ~60%. Caryophyllene follows as the secondary terpene.
Is First 48 good for daytime use?
First 48 is versatile and works across different times of day depending on dose and individual response.
How accurate is this data?
See the "Data confidence" card in the sidebar. Terpene profiles and effects are chemistry-informed estimates — individual responses depend on phenotype, source, and personal chemistry.