Guava Runtz is a modern hybrid strain whose exact origins remain undocumented. While the lineage is sometimes associated with Pink Runtz, breeders have not publicly confirmed the specific cross or the complete genetic history of the plant, leaving the ancestral background currently unverified. This lack of clear provenance is common for modern hybrids, and no institutional breeder history is available to substantiate its development.

The chemical profile of Guava Runtz is complex, characterized by a dominant presence of caryophyllene followed by limonene, linalool, beta-pinene, humulene, pinene, and myrcene. Its THC content is reported as an estimated 17.5%, providing a baseline for its potency. Cultivation of this strain is considered to be of moderate difficulty, performing well in both indoor and outdoor environments. Growers can expect an estimated high yield, with the plant typically completing its flowering cycle within 60 days.

Users of Guava Runtz commonly report experiences of feeling relaxed, happy, and uplifted. Due to these effects, the strain is frequently selected as an option for those seeking relief from stress, pain, and sleep difficulties. There are currently no recorded offspring for this variety, marking it as a distinct, singular entry in the modern hybrid lineage.