A.M.S.
Modern
MOhybrid
Mainline OG
Top flavors
earthyspicycitrus
Terpenes
CalmingEnergizing
Mainline OG effects are mostly calming.
Mainline OG
Mainline OG is a modern hybrid strain with an undocumented lineage. Developed for cultivators seeking a robust production profile that thrives in both indoor and outdoor environments, this strain is noted for its reliable performance. Growers can expect a high yield from this plant, which maintains a moderate difficulty level and reaches maturity after a 63-day flowering period.
The chemical character of Mainline OG is defined by a terpene profile led by myrcene, followed by caryophyllene and limonene as the secondary and tertiary compounds. This specific combination influences the sensory experience, grounding the aromatic profile in the earthy and musky notes provided by the dominant myrcene, while caryophyllene and limonene contribute subtle complexity to the overall flavor and bouquet.
As a THC-dominant cultivar, Mainline OG is frequently sought for its capacity to produce relaxed, happy, and uplifted effects. These qualities make it a practical selection for individuals addressing stress, pain, or difficulties with sleep. Beyond its primary application, the strain has established a substantial genetic legacy through numerous notable offspring, including Coal Creek Kush OG, Crisco, Don Draper, GAW, We Not Me, Williams Cherry Cookies, and WuuBerry.
Terpene Profile
Synergies (+) and conflicts (−) are relative to each other within this profile.
myrcene ~60%caryophyllene ~28%limonene ~12%
| Terpene | Share | Character | Likely role |
|---|---|---|---|
| myrcene | ~60% | earthy | relaxing · solo |
| caryophyllene | ~28% | spicy | relaxing · social |
| limonene | ~12% | citrus | social · creative |
Research notes below describe isolated terpene mechanisms and early findings. They do not guarantee effects from this strain and are not medical advice.
Russo 2011: naloxone-sensitive analgesia, potentiates barbiturate sleep; dominant sedating terpenoid; blocks hepatic carcinogenesis by aflatoxin.
~28%
spicy
●●○○
Russo 2011: only terpene that is a selective full CB2 agonist (100 nM); Gertsch et al. 2008: acts as dietary cannabinoid; unique anti-inflammatory and gastric cytoprotective properties.
Russo 2011: increases serotonin in prefrontal cortex + dopamine in hippocampus via 5-HT1A; Johns Hopkins 2024: significantly reduced anxiety vs THC alone.
Effects
Reported effects — derived from terpene chemistry and cannabinoid profile.
◎
relaxed
eveningPrimary endpoint of myrcene+linalool sedating combinations; GABA modulation is the dominant mechanistic driver.
◉
happy
anytime△
uplifted
morningLimonene anxiolytic/antidepressant via serotonin elevation in prefrontal cortex (Russo 2011); mood improvement without full euphoria; key for balanced-1-1 profiles.
Genetic Profile
Balanced Hybrid
■ Indica 50%■ Sativa 50%
Equal indica and sativa genetics. Balanced body and mind effects.
THC-Dominant
High THC, trace CBD. Psychoactive. Full CB1 agonism — euphoria, appetite, analgesia.
Genealogy
Parent data not yet recorded for Mainline OG.
Composite Traits
Where to buy Mainline OG
No verified dispensaries on file — find it on Leafly.
Dispensary Locator
Find which dispensaries near you currently stock Mainline OG.
or enter a city / postcode
Community Reviews
No reviews yet — be the first!
No reviews yet for Mainline OG.
⊕
What would Mainline OG × ? produce?
Predict the terpene profile, effects, and growing traits of a cross. Our gene weaver engine votes on dominant traits from both parents.
Build a cross with Mainline OG →Similar strains
Same primary terpene with overlapping effects.
Frequently Asked Questions
Is Mainline OG indica or sativa?
Mainline OG is modeled here as a balanced hybrid (equal indica and sativa genetics).
What terpene is dominant in Mainline OG?
Myrcene is shown as the dominant terpene at approximately ~60%. Caryophyllene follows as the secondary terpene.
Is Mainline OG good for daytime use?
Mainline OG is versatile and works across different times of day depending on dose and individual response.
How accurate is this data?
See the "Data confidence" card in the sidebar. Terpene profiles and effects are chemistry-informed estimates — individual responses depend on phenotype, source, and personal chemistry.