Mhybrid

Motherlode

Top flavors

spicycitrusfloral
CalmingEnergizing

Motherlode has balanced effects.

Motherlode is a modern hybrid cannabis strain created through the crossing of Double Strawberry Diesel and Killing Fields F2. Its genetic architecture relies on these two specific cultivars to establish its unique performance characteristics, serving as the foundation for the notable offspring known as Motherlode Kush. The variety is suitable for cultivation in both indoor and outdoor environments, requiring a flowering period of 67 days. Growers should anticipate a high yield from this moderate-difficulty strain.

The chemical profile of Motherlode is defined by a complex arrangement of terpenes, led by caryophyllene, limonene, and nerolidol. This primary triad is further supported by humulene, myrcene, and bisabolol, with trace contributions from beta-pinene, pinene, linalool, ocimene, and camphene. This broad combination dictates the sensory experience, balancing the sharper notes of its primary terpenes with the softer, secondary botanical nuances present throughout the terpene stack.

As a THC-dominant hybrid, Motherlode provides users with effects that are consistently characterized as relaxed, happy, and uplifted. These properties make the strain a functional choice for those seeking relief from stress and pain, as well as those looking for assistance with sleep. Through its genetic lineage, the plant has established a measurable impact on the market, most notably evidenced by its role in the development of Motherlode Kush.

Terpene Profile

Synergies (+) and conflicts (−) are relative to each other within this profile.

caryophyllene ~60%limonene ~28%nerolidol ~12%
TerpeneShare
caryophyllene~60%
limonene~28%
nerolidol~12%

Research notes below describe isolated terpene mechanisms and early findings. They do not guarantee effects from this strain and are not medical advice.

~60%

spicy

●●○○

Russo 2011: only terpene that is a selective full CB2 agonist (100 nM); Gertsch et al. 2008: acts as dietary cannabinoid; unique anti-inflammatory and gastric cytoprotective properties.

~28%

citrus

●●○○

Russo 2011: increases serotonin in prefrontal cortex + dopamine in hippocampus via 5-HT1A; Johns Hopkins 2024: significantly reduced anxiety vs THC alone.

~12%

floral

●●○○

Russo 2011: sedative properties; enhances transdermal pharmaceutical penetration; antimalarial; PMC11060501: GABAergic-mediated antinociception.

Effects

Reported effects — derived from terpene chemistry and cannabinoid profile.

Genetic Profile

Balanced Hybrid

■ Indica 50%■ Sativa 50%

Equal indica and sativa genetics. Balanced body and mind effects.

THC-Dominant

High THC, trace CBD. Psychoactive. Full CB1 agonism — euphoria, appetite, analgesia.

Genealogy

Parentage, ancestry, and genetic relatives of Motherlode.

Composite Traits

Use caution if

evening-wind-downdaytime-productivity

Dispensary Locator

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Community

Top posts from r/trees, r/microgrowery & r/saplings.

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What would Motherlode × ? produce?

Predict the terpene profile, effects, and growing traits of a cross. Our gene weaver engine votes on dominant traits from both parents.

Build a cross with Motherlode

Similar strains

Same primary terpene with overlapping effects.

Frequently Asked Questions

Is Motherlode indica or sativa?

Motherlode is modeled here as a balanced hybrid (equal indica and sativa genetics).

What terpene is dominant in Motherlode?

Caryophyllene is shown as the dominant terpene at approximately ~60%. Limonene follows as the secondary terpene.

Is Motherlode good for daytime use?

Motherlode is versatile and works across different times of day depending on dose and individual response.

How accurate is this data?

See the "Data confidence" card in the sidebar. Terpene profiles and effects are chemistry-informed estimates — individual responses depend on phenotype, source, and personal chemistry.