Original Flo is a modern hybrid strain with an undocumented lineage. Throughout its cultivation history, the plant has established a reputation for reliability in both indoor and outdoor environments. Growers can expect a moderate level of difficulty when maintaining these plants, which reach maturity after a 60-day flowering period and are noted for producing high yields.

The sensory profile of Original Flo is defined specifically by its terpene composition, which is led by myrcene as the dominant terpene, followed by caryophyllene and limonene. This chemical combination dictates the strain's overall bouquet and flavor profile. These primary, secondary, and tertiary terpenes are central to the experience of the plant, providing a distinct olfactory and gustatory nuance consistent across various phenotypes.

As a THC-dominant variety, Original Flo presents effects that are characterized by sensations of being relaxed, happy, and uplifted. These attributes make the strain a functional choice for those seeking to address stress, pain, or difficulties with sleep. Beyond its immediate usage, the strain serves as a significant genetic contributor, as evidenced by its notable offspring which include Delta 9, Isis, Jekyll Passion, M-32, and Skunk Haze.