Permanent Marker is a modern hybrid-indica strain developed through the crossbreeding of Biscotti, Jealousy, and Sunset Sherbet. Cultivation of this strain is considered difficult and requires an indoor environment to reach its full potential, with a flowering period that typically spans 63 days before offering a medium yield. The strain has served as a foundation for modern genetics, with notable offspring including Gas Mark 10, White Iverson, Alien Paya, Creamy & Minty, Highlighter, Permanent Chimera, Permanent Marker x Zsunami, RFF, Sticky Rice, Trauma, Zkittelato, and All Starz.

The sensory profile of Permanent Marker is defined by a complex terpene hierarchy, led by caryophyllene, myrcene, limonene, linalool, humulene, pinene, beta-pinene, bisabolol, and terpinolene. This chemical composition results in an aromatic experience reflecting the distinct contributions of these specific aromatic compounds.

As a THC-dominant cultivar with 21% THC, Permanent Marker is categorized by its capacity to produce relaxed, happy, and sleepy effects. These qualities make it a frequent selection for consumers managing stress, anxiety, or seeking assistance with sleep. Its influence on the current cannabis landscape is evidenced by its use in breeding programs, establishing it as a contributor to the modern gene pool.