Duppy's Cookies is a modern hybrid strain created through the crossing of Watermelon Zkittlez and Do-Si-Dos. Information regarding the specific history and the breeder of this variety remains undocumented, leaving the origins of the strain without a recorded narrative or established timeline. As a modern hybrid, it possesses no status as a landrace or heirloom variety.

The terpene profile of Duppy's Cookies is confirmed to contain a complex matrix led by caryophyllene, limonene, and humulene, followed by linalool, bisabolol, myrcene, beta-pinene, terpinolene, and pinene. Cultivators report a flowering time of one day shorter than standard industry averages, and the strain carries a moderate difficulty rating for those growing in both indoor and outdoor environments. Successfully managed crops are known to produce a high yield.

Consumers can expect THC-dominant effects that are primarily characterized as relaxed, happy, and uplifted. These physiological and psychological outcomes make the strain a functional choice for those seeking relief from stress, pain, or difficulty with sleep. To date, there are no recorded or notable offspring of Duppy's Cookies, positioning the strain as a standalone genetic link in its current lineage.